Curli provide the template for understanding controlled amyloid propagation
نویسندگان
چکیده
منابع مشابه
Congo Red Interactions with Curli-Producing E. coli and Native Curli Amyloid Fibers
Microorganisms produce functional amyloids that can be examined and manipulated in vivo and in vitro. Escherichia coli assemble extracellular adhesive amyloid fibers termed curli that mediate adhesion and promote biofilm formation. We have characterized the dye binding properties of the hallmark amyloid dye, Congo red, with curliated E. coli and with isolated curli fibers. Congo red binds to cu...
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Curli amyloid fibers are the major protein component of the extracellular matrix produced by Enterobacteriaceae during biofilm formation. Curli are required for proper biofilm development and environmental persistence by Escherichia coli. Here, we present a complete and vetted genetic analysis of functional amyloid fiber biogenesis. The Keio collection of single gene deletions was screened on C...
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Fragments of prostatic acid phosphatase (PAP248-286) in human semen dramatically increase HIV infection efficiency by increasing virus adhesion to target cells. PAP248-286 only enhances HIV infection in the form of amyloid aggregates termed SEVI (Semen Enhancer of Viral Infection), however monomeric PAP248-286 aggregates very slowly in isolation. It has therefore been suggested that SEVI fiber ...
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We propose an unsupervised approach to constructing templates from a large collection of semantic category names, and use the templates as the semantic representation of categories. The main challenge is that many terms have multiple meanings, resulting in a lot of wrong templates. Statistical data and semantic knowledge are extracted from a web corpus to improve template generation. A nonlinea...
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During biofilm formation, Escherichia coli and other Enterobacteriaceae produce an extracellular matrix consisting of curli amyloid fibers and cellulose. The precursor of curli fibers is the amyloidogenic protein CsgA. The human systemic amyloid precursor protein transthyretin (TTR) is known to inhibit amyloid-β (Aβ) aggregation in vitro and suppress the Alzheimer's-like phenotypes in a transge...
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ژورنال
عنوان ژورنال: Prion
سال: 2008
ISSN: 1933-6896,1933-690X
DOI: 10.4161/pri.2.2.6746